Publications

 

Guo, S.; Nguyen, L*; Ranum, L. P. W*. RAN proteins in neurodegenerative disease: repeating themes and unifying therapeutic strategies, Curr. Opin. Neurobiol. 2022, 72, 160-170. PMID: 34953315 (*co-corresponding author)

 

Tusi, S. K.; Nguyen, L.; Thangaraju, K.; Cleary, J. D.; Zu, T.; Ranum, L. P. W. The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG• CAGG repeats. Hum. Mol. Genet. 2021, 30, 1020-1029. PMID: 33856033

 

Pattamatta. A.; Nguyen, L.; Olafson, H.; Scotti, M.; Liu, Y.; Richardson, J.; Berglund, A. J.; Zu, T.; Wang E. T.; Ranum, L. P. W. Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice. Human Molecular Genetics, 2021, 29, 3900-3918. PMID: 33378537

 

Nguyen, L.*; Laboissonniere, L. A.*; Guo, S.*; Pilotto, F.; Scheidegger, O.; Oestmann, A.; Hammond J. W.; Li, H.; Hyysalo, A.; Peltola, R.; Pattamatta, A.; Zu, T.; Voutilainen, M. H.;  Gelbard, H. A.; Saxena, S.; Ranum, L. P. W. Survival and motor phenotypes in FVB C9-500 ALS/FTD BAC transgenic mice reproduced by multiple labs, Neuron, 2020, 108, 1-13. (*co-first author). PMID: 33022226

 

Zu, T.; Bardhi, O.; Guo. S.; Ryskamp, D.; Tusi S. K; Liu, Y.; Klippel, K.; Chakrabarty, P.; Nguyen, L.; Golde T. E., Sonenberg, N.; Ranum L. P. W. Metformin inhibits RAN translation through PKR pathway and corrects ALS/FTD phenotypes in C9orf72 mouse model. Proc. Natl. Acad. Sci. U.S.A, 2020, 117(31), 18591-18599. PMID: 32690681

 

Nguyen, L.; Montrasio, M.; Pattamatta, A.; Tusi, S. K.; Bardhi, O.; Meyer, K. D.; Hayes, L.; Nakamura, K.; Banez-Coronel, M.; Coyne, A.; Guo, S.; Laboissonniere, L. A.; Gu, Y.; Narayanan, S.; Smith, B.; Nitsch, R. M.; Kankel, M. W.; Rushe, M.; Rothstein, J.; Zu, T.; Grimm, J.; Ranum, L. P. W. Antibody therapy targeting RAN proteins rescues C9 ALS/FTD in C9orf72 mouse model, Neuron, 2020, 105(4), 645-662. PMID: 31831332

 

Nguyen, L.; Cleary, J. D.; Ranum, L. P. W. Repeat associated non-ATG translation: molecular mechanisms and contribution to neurologic disease, Annu. Rev. Neurosci. 2019, 42, 227-24. PMID: 30909783

 

Chu D. T.; Minh Nguyet N. T.; Nga V. T.; Thai Lien N. V.; Vo D. D.; Nguyen L.; Nhu Ngoc V. T.; Son L. H.; Le D. H.; Nga V. B.; Van Tu P.; Van To T.; Ha L. S.; Tao Y.; Pham V. H.; An update on obesity: Mental consequences and psychological interventions, Diabetes Metab Syndr. 2019; 13(1), 155-160. PMID: 30641689

 

Bai, Y.*; Nguyen, L.*; Song, Z.*; Peng, S.; Zheng, N.; Lee, J.; Kapoor, I.; Cheng, J.; Chan, W.-Y.; Zimmerman, S. C. Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multi-targeting, J. Am. Chem. Soc. 2016, 138, 9498–9507. (*co-first author). PMID: 27355522

 

Luu, M. L*; Nguyen, L.*; Chan, W.-Y.; Zimmerman, S. C. A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy, ChemMedChem 2016, 11, 1428-1435. (*co-first author). PMID: 27245480

 

Nguyen, L.; Luu, M. L.; Peng, S.; Serrano, F. J; Chan, W.-Y.; Zimmerman, S. C. Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1, J. Am. Chem. Soc. 2015, 14180–14189. (UIUC news). PMID: 26473464

 

Nguyen, L.; Lee, J.; Wong, C.-H.; Zimmerman, S. C. Small Molecules that Target the Toxic RNA in Myotonic Dystrophy Type 2, ChemMedChem 2014, 9, 2455–2462. (designated VIP, highlighted on the journal cover). PMID: 24938413

 

Wong, C.-H.; Nguyen, L.; Peh, J.; Luu, L. M.; Sanchez, J. S.; Richardson, S. L.; Tuccinardi, T.; Ho, T.; Chan, E. H. Y.; Chan, W.-Y.; Baranger, A. M.; Hergenrother, P. J.; Zimmerman, S. C. Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor, J. Am. Chem. Soc. 2014, 136, 6355−6361. PMID: 24702247

 

Jahromi, A. H.; Fu, Y.*; Miller, K. A.*; Nguyen, L.*; Luu M. L.; Baranger, A. M.; Zimmerman, S. C. Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1, J. Med. Chem. 2013, 56, 9471–9481. (*co-second author). PMID: 24188018

 

Jahromi, A. H.; Nguyen, L.; Fu, Y.; Miller, K. A.; Baranger, A. M.; Zimmerman, S. C. A novel CUGexp·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1, ACS Chem. Biol. 2013, 8, 1037–1043. (highlighted on the journal cover and UIUC news). PMID: 23480597

 

Do, Q. H.; Pham V. T.; Nguyen, L.; Do, Q. C. Analysis of compounds in Aloe vera by gas chromatography-mass spectrometry, Science and Technology office, Vietnam 2010, 2.